Cytochrome P-450 CYP2B1

A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.

Also Known As:

PROD; BROD; 7-Benzyloxyresorufin O-Dealkylase; 7-Pentylresorufin O-Depentylase; CYP 2B1; Cytochrome P450 2B1; 7 Benzyloxyresorufin O Dealkylase; 7 Pentylresorufin O Depentylase; Benzyloxyresorufin O Dealkylase; Cytochrome P 450 CYP2B1; O-Dealkylase, Pentoxyresorufin; Pentoxyresorufin O Dealkylase; Benzyloxyresorufin O-Dealkylase; CYP2B1; Pentoxyresorufin O-Dealkylase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 2: 31
        Cytochrome P-450 CYP2B1: 286
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP2B1: 286
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 2: 31
      - Cytochrome P-450 CYP2B1: 286
    - Aryl Hydrocarbon Hydroxylases: 18
      - Cytochrome P-450 CYP2B1: 286
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 2: 31
        Cytochrome P-450 CYP2B1: 286
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP2B1: 286

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Disease

Drug/Important Bio-Agent (IBA)